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Interessant, wenn sich folgendes bestätigen sollte:

https://www.frontiersin.org/articles...21.695139/full

Highlights

- We used an expert knowledge system to mine and map the knowledge contained in the open-access CORD-19 literature database, to understand why some people are more severely affected by SARS-CoV-2 than others.

- Elevated blood glucose is the most likely single risk factor to explain why, in otherwise healthy patients, disease severity is associated with age and known comorbidities.

- Elevated blood glucose can facilitate virtually every step of the SARS-CoV-2 infection.

- Elevated blood glucose increases glucose in the pulmonary airway surface liquid (ASL), which breaks down the primary innate antiviral defenses of the lungs and facilitates viral infection and replication.

- Elevated blood glucose causes dysregulations in the immune response that facilitates the cytokine storm and acute respiratory distress syndrome (ARDS).

- Elevated glucose levels act synergistically with SARS-CoV-2-dependent inactivation of angiotensin-converting enzyme 2 (ACE2) to escalate the disease to multi-organ failure and thrombotic events.

Vielleicht noch dazu:
The substantial amount of patient data that has become available has allowed the early identification of groups of people at higher risk of the disease progressing to a severe form and with a higher mortality rate. Of all COVID-19 deaths, more than 50% are patients over 80 years old (Supplementary Figure 1A). Indeed, the case fatality rate (CFR; the percentage of deaths among positively diagnosed infections) increases sharply with age: from <1% below the age of 50 years, to 2*3% around 60 years, and as much as 10*20% above the age of 80 (Supplementary Figure 1B). The main risk factors that add to this age-related CFR include hypertension, cardiovascular diseases, diabetes mellitus (DM) and severe obesity (18*24), with varying impact depending on the country (25). The precedent SARS-CoV-1 showed a similar clinical profile and also affected more severely the elderly and those with diabetes and hypertension (26*28). In fact, the mortality rate (MR; the percentage of deaths among all people) increases with age for many other diseases as well, and patients with diabetes, hypertension or cardiovascular disease are also more susceptible to succumbing to a range of diseases (29, 30), including even seasonal influenza infections (31, 32).

A puzzling aspect of COVID-19 is why the disease becomes so severe with age and preconditions, and in some apparently healthy or young patients. Most of these critical cases seem to be associated with a *cytokine storm* in the lungs (33, 34), an exaggerated immune response that produces high levels of cytokines that damages the airway epithelium, leading to acute respiratory distress syndrome (ARDS), requiring ventilation or intensive care with intubation, which is fatal in 20*50% of cases (24, 35*38). Survivors of the cases that require invasive ventilation also need long-term rehabilitation (39). The 20*50% deaths in intensive care units (ICU) is due to respiratory failure, multi-organ failure and/or septic shock (40, 41). It has furthermore emerged that the virus affects blood coagulation, leading to micro- or macro-vascular thromboses often associated with acute pulmonary embolism and cardiac injury (42*46).